Abstract #2479

Can Diffusion Weighted Imaging/Apparent Diffusion Coefficient Mapping and Dynamic Contrast Magnetic Resonance Imaging Provide Histological Phenotyping of Breast Cancer in Basal and Luminal Subtypes?

Michael A. Jacobs¹, Riham H. El Khouli², Katarzyna J. Macura¹, Sarah Mezban¹, Ihab Kamel¹, David A. Bluemke²

¹The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States; ²Department of Radiology and Imaging Sciences, National Institutes of Health, Bethesda, MD, United States

By using a combined DWI/ADC and DCE approach to investigate histological characteristics of breast cancer a better understanding of breast cancer aggressiveness can be realized. Functional imaging such as DWI and DCE-MR is feasible and thus, combined DWI/ADC mapping, and DCE-MR provides radiological biomarkers of molecular environment and could provide targets for image-guided biopsy of highly aggressive tumor regions.