Abstract #2476

Improved Diagnostic Accuracy in DCE MR-Mammography by Normalization of Kinetic Parameters Following AIF Deconvolution

Endre Grvik¹, Kjell-Inge Gjesdal², Kathinka Kurz Dhli³, Atle Bjrnerud⁴

¹University of Oslo, Oslo, Norway; ²Sunnmre MR-klinikk, Aalesund, Norway; ³Stavanger University Hospital, Stavanger, Norway; ⁴Rikshospitalet University Hospital, Oslo, Norway

This work presents a method for improving diagnostic accuracy in DCE MR-mammography by normalization of kinetic parameters following AIF deconvolution. The permeability related kinetic parameter Ktrans and the Ktrans-ratio between cancer tissue and breast parenchyma were investigated and compared based on their ability to differentiate between malignant and benign lesions. The result showed that employing a normalization approach may improve the diagnostically performance of the pharmacokinetic model by diminishing the prospective errors in the extracted AIF.