Abstract #2437

Diffusion Tractography of the Motor Pathway in High Grade Brain Tumor Patients: A Comparison of Constrained Spherical Deconvolution (CSD) and DTI Algorithms

Bradford Moffat¹, Christopher Steward¹, Patricia Desmond¹, Simon Salinas¹, Andrew Morokoff², Chris Kokkinos³

¹Radiology, University of Melbourne, Melbourne, VIC, Australia; ²Surgery, University of Melbourne, Melbourne, VIC, Australia; ³Radiology, Royal Melbourne Hospital, Melbourne, VIC, Australia

The aim of this study was to investigate whether a probabilistic tractography algorithm based on CSD (SDPROB) was superior for visualisation of the motor pathway in patients with high grade brain tumors. Track volume intersection (TVI) with independent fMRI identified eloquent cortex from SDPROB tractography was compared to traditional stream tracking algorithms based on CSD (SDST) and DTI eigenvectors (DTST). SDPROB was found to be significantly (p<0.01) superior to both SDST and DTST algorithms for mapping the motor pathway to the eloquent motor cortex.