Nasim Maleki1, Jaymin Upadhyay1,
Jennifer Potter2, Roger Weiss, Lino Becerra1,3, David
Borsook1
1PAIN Group, McLean Hospital, Harvard
Medical School, Belmont, MA, United States; 2Division of Alcohol
and Drug Abuse, Dept. of Psychiatry, McLean Hospital, Harvard Medical School,
Belmont, MA, United States; 3Martinos Center, Massachusetts
General Hospital, Charlestown, MA, United States
White
matter abnormalities in a cohort of prescription opioid dependent subjects
(vs. demographically matched subjects) are assessed by combining the parcellated
structural and DTI data. Our results show that there are significant changes
in white matter in the patient group
in the form of reduced fractional anisotropy. The approach used in
this study to evaluate white matter integrity has the major advantage of
taking individual anatomical differences into account for DTI analysis.