Daniel Jon Peterson1, Sheryl L. Rimrodt2,3,
Laurie E. Cutting4
1Developmental Cognitive Neurology, The
Kennedy Krieger Institute, Baltimore, MD, United States; 2Division
of Developmental Medicine, Children's Hospital at Vanderbilt, Nashville, TN,
United States; 3Developmental Cognitive Neurology, Kennedy Krieger
Institute, Baltimore, MD, United States; 4Kennedy Center for Research
and Development, Vanderbilt University, Nashville, TN, United States
DTI
was used to investigate differences in white matter fiber orientation between
three groups: children with reading disability (RD), children with
neurofibromatosis type 1 and reading disability (NF1+RD), and typically
developing controls. A voxel-wise statistical test that detects differences
in fiber orientation revealed bilateral differences in the anterior limb of
the internal capsule. In this region, the fiber orientation of controls and
RD subjects were similar, while those of the NF1+RD subjects clearly
differed, with minimal overlap.