Abstract #2404

Brain Neurochemical Effects of Long-Term Sleep Fragmentation Investigated in Mice at 1

Nathalie Just^1,2, Maxime Baud³, Jean-Marie Petit³, Pierre Magistretti^3,4, Rolf Gruetter^1,5

¹LIFMET, CIBM, EPFL, Lausanne, Switzerland; ²Department of Radiology, UNIL, Lausanne, Switzerland; ³Laboratoire de neuronergtique et dynamique cellulaire, EPFL, Lausanne, Switzerland; ⁴Brain and Mind Institute, Lausanne, Switzerland; ⁵Department of Radiology, UNIL and HUG, Lausanne and Geneva, Switzerland

The present study examined the effects of sleep fragmentation (SF) in the hippocampus and the cortex of mice using proton MR spectroscopy at 14.1T. Disruptions in brain sensory processing and cognitive performance were seen during sleep fragmentation. Moreover, there is evidence that SF negatively affects memory and learning. Here, significant decreases in GABA and Lactate concentrations were detected in the hippocampus of mice following sleep fragmentation indicating decreased synaptic function in the hippocampus.