Michael D.
Boska1, Erin McIntyre1, Melissa Lynn Mellon1,
Howard E. Gendelman2
1Radiology, University of Nebraska
Medical Center, Omaha, NE, United States; 2Pharmacology and
Experimental Neurosciences, University of Nebraska Medical Center, Omaha, NE,
United States
Mouse
brain structural and metabolic stability were determined by T1 and
T2 mapping and DTI at 0.7 and 0.9 s of 4 kW FBMI and by
quantitative single voxel PRESS, respectively. Measures were taken in-vivo before and
repetitively, at 1.17 hour intervals, after FBMI. Analysis continued for a total
duration of 16 hours at room temperature.
The longer FBMI duration was best for maintaining metabolite levels in
the mouse brain; whereas T1, T2, and DTI metrics were
best maintained by shorter duration FBMI.