1University of
An
in vitro proton MRS study was carried out on mice ranging from 3 to 18 months
in order to investigate cerebral metabolic differences between TASTPM
Alzheimer's mice and their wild type base strain. An effect of genotype was
observed for myo-inositol, with concentration being higher in TASTPM mice,
myo-inositol may therefore be an Alzheimer's marker. Lower levels of
succinate were observed in TASTPM mice, being an effect of both age and
genotype. This may indicate impaired neuronal energy production or
mitochondrial dysfunction. The results also call into question the use of
creatine as a reference metabolite.