Nathalie
Just1,2, Maria-Isabel Cordero Campana3,4, Guillaume
Poirier3, Hongxia Lei1,2, Carmen Sandi3,
Rolf Gruetter1,5
1LIFMET, CIBM, EPFL, Lausanne,
Switzerland; 2Department of Radiology, UNIL, Lausanne,
Switzerland; 3Laboratory of Behavioural Genetics, EPFL, Brain and
Mind Institute, Lausanne, Switzerland; 4Department of Child and
Adolescent Psychiatry, HUG, Geneve, Switzerland; 5Department of
Radiology, UNIL and HUG, Lausanne and Geneva, Switzerland
The
rat lateral septum has been shown to be involved in the expression of
anxiety-behaviors such as those involved in conflict procedures. The
neurochemical profile of the lateral septum has however never been
characterized using proton magnetic resonance spectroscopy in the rat. In the
present work, the neurochemical profile of the rat lateral septum was
measured at 9.4T using 1H-MRS demonstrating significant changes compared to similar
data measured in unspecific rat brain regions. It appears essential to
characterize the metabolic profile of specific brain areas with accuracy
using 1H MRS.