Steven R. Roys1,2, Anjaneyulu Murugundla3,
Su Xu1, Aurora Anderson3, Jiachen Zhuo1,
Mark Limsam3, J Choi3, Lauren Koch4, Steve
Britton4, Krish Chandrasekaran3, Paul Yarowsky5,
James Russell3, Rao P. Gullapalli1,2
1Diagnostic Radiology & Nuclear
Medicine, University of Maryland School of Medicine, Baltimore, MD, United
States; 2Core for Translational Research in Imaging @ Maryland
(C-TRIM); 3Neurology, University of Maryland School of Medicine,
Baltimore, MD, United States; 4Anesthesiology, University of
Michigan, Ann Arbor, MI; 5Experimental Therapeutics and
Pharmacology, University of Maryland School of Medicine, Baltimore, MD,
United States
Very
little is understood regarding CNS changes that lead to various cognitive
impairments among people with impaired glucose tolerance. Even less is understood regarding the
differences between high performing diabetic patients versus the low
performing diabetics. The purpose of
this study was to examine the neurochemical profile differences between low
capacity runner rats (LCR) and high capacity runner rats (HCR) using proton
magnetic resonance spectroscopy at 7.0 Tesla.
Findings suggest that LCR rats have elevated taurine, myo-inositol,
glutamate and choline containing compounds compared to HCR rats consistent
with similar findings in diabetic patients.