Adriaan
Campo1, Ove Wiborg2, Helene Benveniste3,
Annemie Van Der Linden1
1Bio-Imaging Lab, University of
Antwerp, Antwerp, Belgium; 2Center for psykiatrisk forskning,
rhus Universitetshospital Risskov, Risskov, rhus, Denmark; 3Medical
Department, Brookhaven National Laboratory, Upton, NY, United States
MR
spectroscopy was used to assess neurochemical changes in the hippocampus of
the CMS rat model for depression. Besides the well known anhedonic phenotype,
and control animals, a third group of animals was included: so-called stress
resilient animals. These animals show different symptoms when subjected to
prolonged stress. We suppose that these different sings of depression are due
to different modulation of the HPA axis, as assessed by glutamate levels in
the hippocampus: normal stressed animals show higher glutamate concentration,
while the abnormal subgroup shows similar glutamate concentration as the
control animals.