Moon-Hyun Yoon1, Hyun-Jin Kim2,
Jin-Yeung Jang2, Bo-Young Choe1
1Biomedical Engineering, Medical
College, The Catholic Univ. of Korea, Seoul, Metro of Seoul, Korea, Republic of; 2Lee
Gil Ya Cancer and Diabetes Institute, GACHON University of medicine and
Science, Seoul, Korea, Republic of
We
found that inflammatory process was significantly associated with the highest
peak height value of MTR histogram in the striatum and the SN. A possible
explanation for this could be the early phase of the influence of specific
neurotransmitters on the mean MTR values. The higher peak height of the MTR
histogram in the striatum and SN was significantly associated with higher
Glx/Cr ratios after MPTP intoxication suggesting neuronal dysfunction. The
pathological studies in PD model clearly demonstrate the presence of
disseminated activated microglial-like inflammatory cells in the central
nervous system.