Alejandra Sierra1, Kimmo Lehtimki1,2,
Teemu Laitinen1, Lassi Rieppo3,4, Asla Pitknen1,5,
Olli Grhn1
1Department of Neurobiology, A.I.
Virtanen for Molecular Sciences, University of Kuopio, Kuopio, Finland; 2Cerebricon
Ldt., Kuopio, Finland; 3Department of Physics, University of
Kuopio, Kuopio, Finland; 4Department of Anatomy, Institute of
Biomedicine, University of Kuopio, Kuopio, Finland; 5Department of
Neurology, Kuopio University Hospital, Kuopio, Finland
Diffusion
tensor imaging (DTI) in combination with tract-based spatial statistics
(TBSS) analysis provides valuable anatomical information about changes in
brain areas contributing to epileptogenic process. Lateral thalamic nuclei
are one of the areas highlighted in TBSS showing increased FA 6 months after
status epilepticus in rats. The present work is focused to characterize the
interrelationship of histopathological changes and ex vivo DTI in combination with TBSS analysis using several
histological stainings and polarized light microscopy.