Ryan Chamberlain1, Malgorzata Marjanska1,
Gregory Preboske2, Linda Kotilinek3, Thomas M.
Wengenack4, Joseph F. Poduslo4, Karen H. Ashe3,
Michael Garwood1, Clifford R. Jack2
1Center for Magnetic Resonance
Research, University of Minnesota, Minneapolis, MN, United States; 2Department
of Radiology, Mayo Clinic, Rochester, MN, United States; 3Department
of Neurology, University of Minnesota, Minneapolis, MN, United States; 4Departments
of Neurology, Neuroscience, and Biochemistry, Mayo Clinic, Rochester, MN,
United States
The
histological abnormalities that characterize Alzheimers disease are commonly
divided into three major classes: amyloid plaques, neurofibrillary tangles
and neurodegeneration. Much work has
been done to image amyloid plaques using the APP/PS1 mouse model. However, the APP/PS1 model was developed to
study amyloid plaques, and neurodegenerative changes are minimal in this
model. The Tg4510 mouse model recapitulates neurodegeneration mediated
through over expression of mutant human tau.
In this work we compare the ability of various MR techniques (volume,
T1ρ, T2ρ, ADC, FA) to detect neurodegeneration in the Tg4510 mouse
model compared to wild-type mice.