Xiaodong Zhang1, Chao He2, Lihong
Hui3, Xiaoying Wang, 1,3, Sheng Xie3,
Jiangxi Xiao3, Hongyu An4, Jue Zhang1,2,
Jing Fang1,2
1Academy for Advanced Interdisciplinary
Studies, Peking University, Beijing, China; 2College of
Engineering, Peking University, Beijing, China; 3Dept.of
Radiology, Peking University First Hospital, Beijing, China; 4Dept.
of Radiology, University of North Carolina at Chapel Hill, Chapel Hill, NC,
United States
Cerebral
oxygen extraction factor (OEF) provides critically important information to
assess the brain oxygen metabolism in both normal and disease states. It has
been reported that the OEF could be evaluated for healthy human volunteers
using MRI. In this study, a based gradient echo sampling of the spin echo
(GESSE) sequence implemented on GE 3.0T scanner to evaluate the cerebral OEF
distribution of rabbits before and after carotid artery occlusion operation.
Our study demonstrated a consistent and significant increase of OEF in
rabbits post carotid artery occlusion, suggesting that this MR based method
can be utilized to detect pathophysiological changes in cerebral oxygenation.