Clinically-Driven Fast and High-Resolution Mapping of T1, M0, and B1 with Whole Brain Coverage

Mohammad Sabati¹, Baranavasi Govindaraju¹, Andrew Maudsley¹

Quantitative MR techniques, such as accurate mapping of the longitudinal relaxation time and water content, have become more important in neurological research. The current T1 mapping methods are generally lengthy and not adequate in a clinical environment. Also, further acquisitions are usually required to obtain the brain tissue water content. Several factors, including RF field inhomogeneities and low SNR impair the accuracy of these methods. In this study, we present a modified two-acquisition SPGR method for simultaneous B1, T1, and M0 mapping with a 1-mm isotropic spatial resolution that covers the entire human brain in a clinically acceptable time.