Chunming Xie1,
Liping Fu2, Lin Ma3, Wenjun Li1, Alex Cohen1,
Zheng Yang2, Shi-Jiang Li1
1Medical College of Wisconsin,
Milwaukee, WI, United States; 2Beijing Institute of Basic Medical
Science, Beijing, China; 3Department of Radiology, The PLA General
Hospital, Beijing, China
The
purpose of this study was to investigate the neuropsychological underpinnings
of impulsive network on abstinent heroin addicts using resting-state functional
connectivity method. Heroin subjects showed the higher impulsive scores and
abnormal amygdala networks activity. The altered amygdala network strengths
significantly correlated with impulsivity, and different correlation patterns
were fund in heroin subjects relative to control subjects. This finding
indicated the neural constructs of impulsive network was different in these
two group subjects and altered amygdala network activity in heroin subjects
makes a critical contribution to the impulsive dysfunction and represents the
pathological damage underlying the impulsive control.