Qiang Shen1,2, Fang Du1, Shiliang
Huang1, Timothy Q. Duong1,2
1Research Imaging Institute, University
of
Regional
hyperperfusion after stroke is a frequent, yet poorly understood, phenomenon.
In this study, multimodal MRI (diffusion, perfusion, T2, T1, pH-weighted and
dynamic contrast-enhanced imaging, and MRA) were acquired in a 30-min
transient MCAO in rat. Significant hyperperfusion was observed 24hrs
post-occlusion and peaked at 48hrs. Hyperperfusion areas were consistent with
regions with T1 and T2 increases, and early-phase pH decrease, and late-phase
permeability changes. MRA showed significant vasodilatation of distal small
arteries. We conclude that hyperperfusion does not appear to salvage tissue.
Multimodality MRI investigation helps to gain significant insights into the
underlying physiological changes associated with hyperperfusion.