Franklyn Arron Howe1, Tom R. Barrick2,
Greg A. Fellows3, Alan J. Wright4
1Cardiac & Vascular Sciences , St
George's, University of London, London, United Kingdom; 2Clinical
Neuroscience, St George's, University of London, London, United Kingdom; 3Academic
Neurosurgery, St George's, University of London, London; 4Radiology,
UMC st. Radboud University Hospital, Nijmegen, Netherlands
Metabolic
information from 1H MRSI may aid image segmentation using DTI and so improve
delineation of infiltrative brain tumours such as gliomas. NAA and fractional
anisotropy (FA) are expected to decrease with tumour infiltration and loss of
neuronal structure, but FA calculated from principal diffusion magnitude
images is biased due to the contribution of noise. We have investigated the
FA and NAA distribution in glioblastomas in comparison to simulated data that
takes into account the effect of SNR on the measurement of low FA values. Our
data provides evidence for diffusion anisotropy in glioblastomas in the
absence of functional neurones.