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Abstract #2197

Assessment of Invasion and Recurrence in Glioblastoma Multiforme Using Diffusion Weighted MRI Edge Characteristics of Contrast Enhancing Tumor

Peter Sherman LaViolette1,2, Benjamin M. Ellingson, 2,3, Jennifer M. Connelly, 2,4, Mark G. Malkin, 2,4, Scott D. Rand, 2,3, Kathleen M. Schmainda1,2

1Biophysics, Medical College of Wisconsin, Milwaukee, WI, United States; 2Translational Brain Tumor Program, Medical College of Wisconsin, Milwaukee, WI, United States; 3Radiology, Medical College of Wisconsin, Milwaukee, WI, United States; 4Neurology, Medical College of Wisconsin, Milwaukee, WI, United States


Traditionally, brain tumor recurrence is defined as new MRI contrast enhancement apparent in follow-up imaging. This study shows that diffusion weighted MRI edge characteristics of contrast enhancing tumors show measurable differences indicative of tumor invasion prior to contrast enhancing recurrence