Irene Neuner1,2, Joachim Bernhard Maria
Kaffanke1, Cornelius Werner1,2, Martina Reske1,3,
Karl-Joseph Langen1, Hans Herzog1, N. Jon Shah1,2
1Institute of Neurosciences and
Medicine 4, Medical Imaging Physics, Forschungszentrum Jlich GmbH, 52425
Juelich, Germany; 2Faculty of Medicine, Department of Neurology,
RWTH Aachen University, 52074 Aachen, Germany; 3Department of
Psychiatry, University of California San Diego, San Diego, CA, United States
For
the planning of surgical intervention in human brain tumour cases, it is
important to know if critical brain areas might be affected by the surgical
process itself. PET imaging using radiolabelled amino acids is a valuable
technique for the diagnosis of cerebral gliomas.
O-(2-[18F]Fluorethyl)-L-Tyrosin (FET) is a well established amino acid tracer
that delivers information about tumour extent, the optimal biopsy site and
detection of tumour recurrences. In this study, FET-PET and BOLD-fMRI data
were acquired simultaneously; data from a representative human brain tumour
case are presented. In contrast to task-based functional studies, resting
state fMRI offers the opportunity to detect a variety of cortical networks in
a single experiment.