Anitha Priya Krishnan1, Delphine Davis2,3,
Paul Okunieff3, Walter G. O'Dell, 1,3
1Biomedical Engineering, University of
Rochester, Rochester, NY, United States; 2Imaging Sciences,
University of Rochester, Rochester, NY, United States; 3Radiation
Oncology, University of Rochester, Rochester, NY, United States
The
current methods for determining the treatment margin for Stereotactic
Radiotherapy of gliomas are inadequate as recurrences often occur at the
boundary of the treatment margin. We developed a random walk model to
determine the microscopic spread of tumor cells to facilitate in the
development of anisotropic treatment margins. In this study we have shown that
the affinity of cancer cells to fibers in the brain can be modeled better by
the spread in the direction of migration about the Principal Diffusion
Direction determined using DTI than by using a variable step-size in the
random walk of cancer cells.