Parametric Response Map as an Imaging Biomarker to Distinguish Progression from Pseudoprogression in High Grade Gliomas

Christina Tsien¹, Craig J. Galban¹, Thomas L. Chenevert¹, Timothy D. Johnson¹, Daniel A. Hamstra¹, Pia C. Sundgren¹, Larry Junck¹, Charles R. Meyer¹, Alnawaz Rehemtulla¹, Theodore Lawrence¹, Brian D. Ross¹

We have developed a reliable method for distinguishing true progression from pseudoprogression by quantifying on a voxel-wise basis therapeutic-associated hemodynamic alterations in patients with high grade glioma. The parametric response map of rCBV (PRM_rCBV) at week 3 during chemoradiation is shown to be a potential early imaging biomarker of response that may be helpful in distinguishing pseudoprogression from true progression in patients with high grade glioma.