1Radiology, University of California,
San Francisco, San Francisco, CA, United States; 2Center for
Imaging of Neurodegenerative Diseases, Veteran Administration Medical Center,
San Francisco, CA; 3Psychiatry, University of California, San
Francisco, San Francisco, CA, United States; 4Center for Imaging
of Neurodegenerative Diseases, Veteran Administration Medical Center, San
Francisco, CA, United States
We
studied NAA, Glu and GABA levels in post traumatic stress disorder using
magnetic resonance spectroscopy. We found lower NAA in the anterior
cingulate, lower GABA in the posterior occipital cortex, and lower GABA and
higher Glu in the medial temporal lobe as compared to control subjects.
Metabolite levels related to PTSD symptomatology and suggest neuronal injury,
perhaps associated with excitatory and inhibitory processes in cortical brain