Ying-Jr Chen1,
Joong Hee Kim1, Jian Wang1, Tsang-Wei Tu, 12,
Sheng-Kwei Song1
1Radiology, Washington University in
St. Louis, Saint Louis, MO, United States; 2Mechanical, Aerospace
and Structural Engineering, Washington University in St. Louis, Saint Louis,
MO, United States
The
sensitivities of detecting white matter injury using 6 ms and 38 ms diffusion
time were examined in the present study. We demonstrated that increased
diffusion time in diffusion tensor imaging measurements improves the
sensitivity of detecting axonal injury and myelin damage in cuprizone treated mice. In the cuprizone
model of demyelination, axonal injury was seen as significantly decreased
axial diffusivity at both 6 and 38 ms diffusion time with more significantly
decreased axial diffusivity observed at longer diffusion time.