Abstract #2135
Hybrid
Diffusion Imaging in a Spinal Cord Model of Dysmyelination
A P. Hosseinbor1, I D. Duncan2, A
L. Alexander, A A. Samsonov3, Y-C Wu4, S A. Hurley, R
A. Fisher, A S. Field3
1Medical Physics, University of
Wisconsin-Madison, Madison, WI, United States; 2Medical Sciences,
University of Wisconsin-Madison; 3Radiology, University of
Wisconsin-Madison; 4Dartmouth College
The
shaking pup (shp) is a canine mutant model of dysmyelination, and suffers
from severe myelin deficiency. In a previous study of shp brain, Po was shown to differentiate between a control and
diseased pup with respect to myelin content. In this study, WM integrity is
examined in the spinal cord of shp using both DTI and DSI measurements
acquired from a HYDI approach. Standard DTI measures and Po
are compared to see if one or both are sensitive to changes in myelin content
between shp and control, as well as to more subtle differences between two
diseased pups.
