Abstract #2126

Voxelwise Analysis of Pelizeaus-Merzbacher Disease in 17 Genetically Proven Cases Using Diffusion Tensor Imaging

Onur Ozyurt¹, Alp Dincer², Zuhal Yapici³, Cengiz Yalcinkaya⁴, Mefkure Eraksoy³, Cengizhan Ozturk¹

¹Bogazici University, Biomedical Engineering Institute, Istanbul, Turkey; ²Acibadem University, School of Medicine, Department of Radiology; ³Istanbul University, Istanbul Faculty of Medicine, Department of Neurology; ⁴Istanbul University, Cerrahpasa Medical Faculty, Department of Neurology

In this study, tract based spatial statistics (TBSS) approach is used for the investigation of Pelizeaus-Merzbacher Disease (PMD), which is a rare X-linked disease characterized by defective central nervous system myelination due to a mutation in the proteolipid protein 1 gene.