Robert Zivadinov1, Paolo Zamboni2,
E. Mark Haacke3, Erica Menegatti4, Bianca
Weinstock-Guttman5, Claudiu Schirda1, Anna M. Malagoni2,
David Hojnacki5, Cheryl Kennedy1, Ellen Carl1,
Niels Bergsland1, Sara Hussein1, Mari Heininen-Brown1,
Ilaria Bartolomei6, Fabrizio Salvi2, Michael G. Dwyer1
1University at Buffalo, Buffalo
Neuroimaging Analysis Center, Buffalo, NY, United States; 2University
of Ferrera- Bellaria Neurosciences, Vascular Diseases Center, Ferrera, Italy;
3MR Research Facility, Wayne State University, Detroit, MI, United
States; 4University of Ferrera- Bellaria Neurosciences, Vascular
Diseases Center, Buffalo, NY, United States; 5University at
Buffalo, The Jacobs Neurological Institute, Buffalo, NY, United States; 6University
of Ferrera- Bellaria Neurosciences, Vascular Diseases Center, Ferrera, NY,
United States
Chronic
cerebrospinal venous insufficiency (CCSVI) is a vascular picture in multiple
sclerosis patients characterized by stenoses affecting the main extracranial
venous outflow pathways and by a high rate of cerebral venous reflux that may
lead to increased iron deposition in the brain. We explored relationship
between venous hemodynamic (VH) parameters and disability and iron
concentration in deep-gray matter (DGM) structures and lesions on
susceptibility-weighted imaging. There was a significant association between
higher number of VH criteria and higher iron concentration in T2 and T1
lesion volumes. Higher iron concentration in DGM structures was strongly
associated with higher disability status.