Cognitive Impairment in Early Multiple Sclerosis Related to Metabolic Impairment in Cerebellum

Wafaa Zaaraoui¹, Franoise Reuter¹, Audrey Rico¹, Irina Malikova¹, Elisabeth Soulier¹, Patrick Viout¹, Yann Le Fur¹, Sylviane Confort-Gouny¹, Patrick J. Cozzone¹, Jean Pelletier¹, Jean-Philippe Ranjeva¹, Bertrand Audoin¹

While metabolic changes and cognitive impairment are known to be present in multiple sclerosis (MS) from the earliest stage of the disease, no exhaustive examinations have been performed to assess potential relationships between metabolite levels and cognitive status. Our study aimed to investigate whether magnetic resonance spectroscopic markers in normal appearing brain tissues are related to cognitive status in multiple sclerosis.