Katherine A. Koenig1, Blessy Mathew1,
Jian Lin1, Lael Stone2, Stephen Rao3,
Michael Phillips1, Mark J. Lowe1
1Imaging Institute, The Cleveland Clinic,
Cleveland, OH, United States; 2Mellen Center, The Cleveland
Clinic, Cleveland, OH, United States; 3Schey Center, The Cleveland
Clinic, Cleveland, OH, United States
Nineteen
patients with MS performed a verbal incidental encoding task, followed by a word
recognition task (WR). Stimuli from the WR task were split into encoded and
non-encoded based on performance of each subject. The encoded stimuli of
the five highest performers were used to create an average t-map to select
regions of interest for a correlation analysis. Areas involved in semantic
encoding, including the DLPFC and the inferior frontal gyrus, showed a
significant positive correlation between the fit hemodynamic response
amplitude during encoded stimuli on the WR task and a test of verbal memory.