Jie Luo1, Pascal Sati2, Anne H.
Cross3, Dmitriy A. Yablonskiy2
1Chemistriy, Washington University in
St.Louis, St. Louis, MO, United States; 2Radiology, Washington
University in St. Louis, St. Louis, MO, United States; 3Neurology,
Washington University in St. Louis, St. Louis, MO, United States
One
reason for the weak correlation between conventional MRI (based on T1/T2
weighted images) and clinical findings is the inability of conventional MRI
to quantify the extent of tissue damage. In this study, we demonstrated that
an efficient method based on GEPCI technique not only depicts MS lesions
similar to conventional T1w and FLAIR images, but also allows quantitative
evaluation of disease progression. Combining characteristics of main peak in
R2* histograms and quantitative score assigned to MS lesions, allows the
evaluation not only of the volume of cerebral MS lesions, but incorporates
the degree of tissue damage as well.