Fuchun Lin1,
Chunshui Yu2, Yaou Liu2, Hao Lei1
1Wuhan Institute of Physics &
Mathematics, The Chinese Academy of Sciences, Wuhan, Hubei, China; 2Department
of Radiology, Xuanwu Hospital of Capital Medical University, Beijing, China
Diffusion
tensor based group tractography was used to determine the corpus callosum
(CC) integrity in clinically isolated syndrome (CIS). Compared to the healthy
subjects, the CIS patients had significantly reduced midsagittal CC area, and
significantly higher MD, λ 1, λ 23 and
significantly lower FA in the entire CC. Moreover, the average FA of the
normal-appearing CC of the CIS patients correlated negatively with the
whole-brain lesion load while the other three diffusion indices correlated
with the lesion load positively. These results suggested that both the
morphology and the microstructure of the CC appear to be damaged at the stage
of CIS.