Julien Cohen-Adad1,2, Douglas Greve1,2,
Thomas Benner1,2, Amy Radding1,2, R Philip Kinkel,
2,3, Bruce R. Rosen1,2, Bruce Fischl1,2, Caterina
Mainero1,2
1A. A. Martinos Center for Biomedical
Imaging, Dept. of Radiology, MGH, Charlestown, MA, United States; 2Harvard
Medical School, Boston, MA, United States; 3Beth Israel Deaconess
Medical Center, Boston, MA, United States
The
ability to detect and to classify in vivo gray matter (GM) lesions in
multiple sclerosis (MS) is required to better understand pathological
processes associated with disease progression and disability. In this paper
we combined ultra high field MRI (7T) with surface-based analysis to achieve
quantitative assessment of subtle and diffuse cortical changes in multiple
sclerosis (MS). Results show a significant increase of the T2* signal in MS
patients versus controls. This increase may reflect the diffuse subpial
pathology that has been described in autopsy cases of MS. Surface-based
analysis facilitates the characterization of cortical lesions in vivo.