Peter Kochunov1, Carlos Castro2,
Gerald Schatten3, David Purdy4, Hsiao-Ying Wey1,
Duff Davis1
1Reseach Imaging Institute, UTHSCSA,
san antonio, TX, United States; 2Ob / Gyn and Reproductive
Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, United
States; 3Pittsburgh Development Center, University of Pittsburgh
School of Medicine, Pittsburgh, PA, United States; 4Siemens
Healthcare USA, Malvern, PA , United States
While
the teratogenic properties of alcohol are well known, the mechanisms by which
alcohol-induced damage is produced in the CNS are still largely unknown. We
present findings of changes in dynamic susceptibility contrast (DSC) in fetal
brain of a non-human primate (baboon) during a protocol designed to
approximate a binge drinking episode. Signal changes in the brain and
uterus/placenta were compared using a pulse sequence protocol with high
temporal and spatial resolution, showing that gadodiamide entered fetal
cerebral circulation following alcohol administration.