Irene Margaret Vavasour1, Cornelia Laule1,
Burkhard Maedler2, Trudy Harris1, David K.B. Li1,
Anthony L. Traboulsee3, Alex L. MacKay1
1Radiology, University of British
Columbia, Vancouver, BC, Canada; 2Physics and Astronomy,
University of British Columbia; 3Medicine, Univeristy of British
Columbia
Quantitative
assessment of 1H-MRS metabolite concentrations has the potential
to be an in-vivo marker for disease progression and treatment efficacy in
pharmaceutical trials. The present study examines cross-site reproducibility
of 1H-MRS metabolite concentrations measured on the same 5 people
at 6 sites. Average percent differences of inter and intra-site
reproducibility was <10% for n-acetyl-aspartate and myo-Inositol, <7%
for creatine, <8% for choline and <21% for glutamate and glutamine. All
percent differences between sites were of a similar magnitude increasing
confidence in comparing results from across the sites.