Chunming Xie1,2, Wenjun Li1,
Joseph Goveas1, Piero Antuono1, Jennifer Jones1,
Guangyu Chen1, Malgorzata Franczak1, Zhilin Wu1,
Shi-Jiang Li1
1Medical College of Wisconsin,
Milwaukee, WI, United States; 2Neurology, School of Clinical
Medicine, Southeast University, Nanjing, Jiangsu, China
The
purpose of this study was to identify neural correlates of depressive
symptoms and memory deficits in the amygdala functional connectivity network
(AFCN) in elderly with or without amnesic mild cognitive impairment (aMCI)
using the resting state functional connectivity MRI technique. aMCI subjects
showed abnormal AFCN activity and the significant different correlation
patterns in the distinct nodes within the AFCN correlated to depressive
symptoms and memory deficits. This suggests the AFCN has dual effects that
link depressive symptoms and memory deficits. The altered neural substrates
of the AFCN underlying the emotional and cognitive functions mediation were
associated with disease state.