Robert John
Dawe1, David A. Bennett2, Julie A. Schneider2,
Konstantinos Arfanakis1
1Department of Biomedical Engineering,
Illinois Institute of Technology, Chicago, IL, United States; 2Rush
Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL,
United States
Postmortem
MRI of the human brain offers several advantages over in vivo imaging. For
example, histological analysis can be performed following the MR scan,
allowing for verification of imaging findings and testing of new MRI
diagnostic techniques. Spatial transformation of individual postmortem brain
MRI volumes to a common reference would facilitate voxel-based
investigations, which would provide information throughout the brain in a
timely manner and without user bias, in contrast to ROI-based analyses. In
this work, population-based methods were used to create an MRI template that
is suitable for high dimensional spatial normalization of postmortem human
cerebral hemispheres.