Lydie Nadal-Desbarats1, Helne Blasco2,
Segolene Veau2, Patrick Vourc'h2, Caroline Moreau3,
David Devos3, Philippe Corcia4, Christian R. Andres2
1Laboratoire de RMN, INSERM U930 - CNRS
2448 - Universit Franois Rabelais, Tours, France; 2Laboratoire
de Biochimie et Biologie moleculaire, Inserm U930-CNRS 2448 - Universit
Franois Rabelais, Tours, France; 3Service de Neurologie et
Pathologie du Mouvement, EA2683, Hopital R. Salengro - CHRU Lille, Lille,
France; 4Centre SLA, CHRU Bretonneau, Tours, France
Amyotrophic
lateral sclerosis is a progressive neurodegenerative disease.
Pathophysiological mechanisms involved in this disease are complex but remain
for the most part unknown. This lack of knowledge might explain the absence
of reliable biological marker. CSF could be a source of biomarkers. The aim
of this study was to analyze CSF of patients with ALS by 1H NMR in order to
identify biomarkers in the early stage of the disease, and to evaluate the
biochemical factors involved in this disease. We quantified 18 metabolites
like amino-acids, organic acids and ketonic bodies. Higher concentrations of
metabolites such as ketone bodies contribute to the PCA separation between
the two populations.