Abstract #1958

Resting-State FMRI Contributes to Differentiate Patients with Dementia with Lewy Bodies from Those with Alzheimer's Disease

Barbara Basile¹, Mara Cercignani¹, Laura Serra², Roberta Perri³, Camillo Marra⁴, Lucia Fadda³, Carlo Caltagirone^3,5, Marco Bozzali²

¹Neuroimaging Laboratory, Santa Lucia Foundation, Rome , Italy, Italy; ²Neuroimaging Laboratory, Santa Lucia Foundation, Rome, Italy, Italy; ³Clinical and Behavioural Neurology Laboratory, Santa Lucia Foundation, Rome, Italy, Italy; ⁴Department of Neurosciences, Catholic University of Rome, Roma, Italy, Italy; ⁵Department of Neurosciences , University of Torvergata, Rome, Italy, Italy

Resting-state fMRI was used to investigate changes of functional connectivity (FC) within specific resting-state networks (RSNs) in the presence of Alzheimer's disease (AD) and dementia with Lewy Bodies (DLB) as compared to normal aging. Using ICA analysis, we identified 10 RSNs across subjects. AD patients revealed reduced FC in the posterior cingulate, within the default-mode-network. Conversely, DLB patients showed reduced FC in occipital areas, within the visual network. These findings respectively account for brain disconnection between medial temporal lobes and other association cortexes in the development of AD symptoms, and for occipital abnormalities potentially responsible for visual hallucinations in DLB.