Hao Huang1, Xin Fan1, Kristin
Martin-Cook2, Guanghua Xiao3, Laura Lacritz4,
Myron Weiner4, Roger Rosenberg2
1Advanced Imaging Research Center,
University of Texas Southwestern Medical Center, Dallas, TX, United States; 2Department
of Neurology, University of Texas Southwestern Medical Center, Dallas, TX,
United States; 3Department of Clinical Sciences, University of
Texas Southwestern Medical Center, Dallas, TX, United States; 4Department
of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX,
United States
The
purpose of this study is to find an effective white matter biomarker of
Alzheimers disease (AD) which may indicate disease severity and progression.
In this study, DTI and T1 weighted images were acquired from 38 subjects (20
AD, 18 controls). We surveyed all white matter tracts by labeling of the ICBM-DTI-81
digital atlas and correlated FA values of individual white matter tracts with
cognitive testing score and cortical atrophy map respectively. The
correlation analyses show that tracts in the limbic system, namely fornix and
cingulum, are the most sensitive tract to cognitive testing scores and
cortical atrophy.