Richard Wong1,2, Tian Liu1,2,
Xiao-Yun Zhu3, Hing C. Wong3, Yi Wang1,4
1Cornell University, Ithaca, NY, United
States; 2Department of Radiology, Cornell University - Weill
Medical College, New York, NY, United States; 3Altor Bioscience
Corp, Miramar, FL, United States; 4Department of Radiology, Weill
Medical College, New York, NY, United States
We
have created an anti-p53 scTCR-SPIO for use as a generalized cancer detection
contrast agent for use in MR. In vitro
models demonstrate the effectiveness of this molecule in labeling
p53-expressing cells and suggests future application in in vivo cancer
models.