Silver Nanoparticles Functionalized with High Gadolinium Chelate Payload as Effective in Vivo T1-Brightening Contrast Agents

Lindsay Kathleen Hill¹, Talha S. Siddiqui², Dung Minh Hoang¹, Susan Pun¹, Marc Anton Walters², Youssef Zaim Wadghiri¹

In the research described here we designed a new silver multimodal nanoparticle containing GdDTPA and tested the effect of coligated polyethyleneglycol (PEG) chains on particle distribution, clearance and contrast enhancement. The resulting GdDTPA content, relaxivity and solubility were characterized in vitro and their biodistribution was assessed by abdominal MRI.