Abstract #1905

Magnetite Liposomes as Potential Theranostic Agents for MRI and Magnetic Hyperthermia of Vascular Inflammation

Hisanori Kosuge¹, Toshiro Kitagawa¹, Takeshi Kobayashi², Michael V. McConnell¹

¹Cardiovascular Medicine, Stanford University, Stanford, CA, United States; ²Biological Chemistry, Chubu University, Kasugai, Aichi, Japan

Inflammation plays a critical role in the progression of atherosclerosis. Magnetite liposomes (MLs) have been used for magnetic hyperthermia of cancer cells and for cellular MR imaging. Thus, they may have the potential to both image and treat vascular inflammatory cells. We demonstrate that MLs show macrophage uptake and effective magnetic hyperthermia and cell death in vitro. ML also imaged mouse carotid vascular inflammation by 7T MRI.