Abstract #1894

Enzyme Mediated MRI Probes: Design, Synthesis and Relaxivity Behaviour of a Beta-Galactosidase Reporter

Eliana Gianolio¹, Jebasingh Bhagavath Singh¹, Markus Aswendt², Francesca Arena¹, Alessandro Barge³, Mathias Hoehn², Silvio Aime¹

¹Chemistry IFM and Molecular Imaging Center, University of Torino, Torino, TO, Italy; ²In-vivo-NMR Laboratory, Max Planck Institute for Neurological Research, Cologne, Germany; ³Department of Drug Science and Technology, University of Torino, Torino, Italy

We report about the synthesis and the characterization of a Gd-DOTAgal derivative that has been proven to be a good -galactosidase expression reporter. It consists in a system that can undergo polymerization in the presence of Tyrosinase upon beta-gal activated cleavage of the tyr-gal bond.