Abstract #1835

Convection Enhanced Delivery of Drugs to the CNS

Peter Andrew Hardy¹, Zhiming Zhang¹, Don Gash¹, Doug U. Gwost², David Stiles², Brian D. Nelson², Pei Ge³, Dinah Sah³

¹Anatomy & Neurobiology, University of Kentucky, Lexington, KY, United States; ²Medtronic Neurological, Minneapolis, MN, United States; ³Alnylam Pharmaceuticals, Inc., Cambridge, Massachussets, United States

Convection Enhanced Delivery is a powerful method of delivering drugs to the CNS. We tested CED hardware and imaging methods by delivering Magnevist at three flow rates to the putamen in rhesus monkeys over a period of 7 days. T1-weighted images were acquired at three time points and from these the volume of distribution was characterized. Results demonstrate a compact distribution to the putamen with a flow rate-dependent volume.