Najat Salameh1, Line Souris1,
Laurent Marsac2, Jean-Franois Aubry3, Mathieu Pernot3,
Benjamin Robert2, Mathias Fink3, Luc Darrasse1,
Mickal Tanter3
1Imagerie par Rsonance Magntique
Mdicale et MultiModalit (UMR 8081), Universit Paris-Sud, CNRS, Orsay,
Iles-de-France, France; 2SuperSonic Imagine, Aix-en-Provence,
France; 3Institut Langevin, ESPCI ParisTech, CNRS UMR 7587 INSERM
U979, Paris, France
A
novel prototype for brain therapy with transcranial focused ultrasound is
presented here. The first part of this study showed that this new HIFU system
was fully MR-compatible. Secondly, we optimized a sequence for MR
thermometry, and followed the increase in temperature in a gel heated with
increasing power (from 125 to 500 Wac). Finally, we showed it is possible to
heat veal brains through a human skull at a high frequency and monitor the
heating process with MRI. After validation on cadaver heads, this work will
open new horizons to tumor brain therapy in animals and then in humans.