Hsu-Hsia Peng1, Teng-Yi Huang2,
Hsiao-Wen Chung3, Shiun-Ying Ju2, Yao-Hao Yang2,
Po-Cheng Chen4, Yu-Hui Ding4, Wen-Shiang Chen4,
Wen-Yih Isaac Tseng5
1Department of Biomedical Engineering
and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan; 2Department
of Electrical Engineering, National Taiwan University of Science and
Technology, Taipei, Taiwan; 3Department of Electrical Engineering,
National Taiwan University, Taipei, Taiwan; 4Department of
Physical Medicine and Rehabilitation, National Taiwan University Hospital,
Taipei, Taiwan; 5Center for Optoelectronic Biomedicine, Medical
College of National Taiwan University, Taipei, Taiwan
In
this study, an imaging sequence, which simultaneously monitors temperature
change and magnetization transfer (MT) contrast at 2-sec temporal resolution,
was applied on rabbit thigh muscle during HIFU sonicaiton to verify in vivo
feasibility. The characteristics of better immunity to phase variance (in
contrast to temperature mapping derived from phase images) and clear
distinction between heated spot (4.29%0.41%) and non-heated region
(-0.19%0.30%) of MT, even after turning off HIFU pulse, suggest its
usefulness in long-term monitoring. In conclusion, MRI with simultaneous
temperature and MT mapping is an effective technique to evaluate tissue
damage for HIFU treatment.