MR Guided HIFU in Cadaver Breasts for Pre-Operative Tumor Localization of Non-Palpable Breast Tumors as an Alternative to Needle Wire Tumor Localization

Rachel R. Bitton¹, Elena Kaye^1,2, Bruce Daniel¹, Kim Butts Pauly¹

Physicians are increasingly confronted with non-palpable breast lesions only visible on MRI. This study examined the visibility and palpability of focused ultrasound lesions in fatty human breast tissue. Eighteen sonications were made around the perimeter of an arbitrary prescribed tumor square, representing a non-palpable tumor area. Potential stiffness changes were measured using MR-ARFI showing the displacement difference between the pre and post sonication. The lesions were fully registered with images, circumscribing a tumor area in a human cadaver breast, and thus, providing a visible and palpable perimeter for a surgeon as a guide for excision during breast conservation surgery.