Kohsuke Kudo1, Soren Christensen2,
Makoto Sasaki1, Matus Straka3, Shunrou Fujiwara1,
Kinya Ishizaka4, Yuri Zaitsu4, Noriyuki Fujima4,
Satoshi Terae4, Kuniaki Ogasawara5, Leif Ostergaard6
1Advanced Medical Research Center,
Iwate Medical University, Morioka, Iwate, Japan; 2Departments of
Neurology and Radiology, University of Melbourne, Melbourne, Australia; 3Department
of Radiology, Stanford University, CA, United States; 4Department
of Radiology, Hokkaido University Hospital, Sapporo, Japan; 5Department
of Neurosurgery, Iwate Medical University, Morioka, Iwate, Japan; 6Department
of Neuroradiology, Aarhus University Hospital, Aarhus, Denmark
A
variety of post-processing programs and algorithms for dynamic susceptibility
contrast (DSC) MR perfusion are available; however, the accuracy and
reliability of these programs have not been subject to a standardized quality
control. We developed digital phantom data set, to evaluate the accuracy and
characteristics of quantitative values derived from DSC perfusion analysis
software. By using this phantom, we could check tracer-delay dependency for
CBF, CBV, MTT, and Tmax, as well as linearity of CBF and MTT against true
values.