Abstract #1789

Improving and Validating a Local AIF Method

Lisa Willats¹, Soren Christensen², Henry Ma³, Geoffrey Donnan^4,5, Alan Connelly^1,5, Fernando Calamante^1,5

¹Brain Research Institute, Florey Neuroscience Institutes (Austin), Melbourne, Australia; ²Department of Radiology, University of Melbourne, Australia; ³National Stroke Research Institute, Florey Neuroscience Institutes (Austin), Melbourne, Australia; ⁴Florey Neuroscience Institutes , Melbourne, Australia; ⁵Department of Medicine, University of Melbourne, Australia

In bolus tracking the perfusion errors associated with bolus delay/dispersion may be minimised using a local Arterial Input Function (AIF) analysis. We improve a previously presented local AIF method by minimising the influence of the Mean Transit Time (MTT) on the local AIF selection. This is particularly important for identifying local AIFs in regions bordering normal and abnormal MTT tissue. We assess the improvement by comparing the amount of delay/dispersion remaining in the deconvolved tissue response after each local AIF approach, and compare both methods with the standard global AIF analysis.